HCM RESULTS
All original forms are at my home and available for viewing by kitten buyers.
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Eventhough both of Ch Cozycreek Super Sonic Sammy's parents have been tested for the predominantly Ragdoll MyBPC mutation (and are DNA negative) I decided that since Sammy will be the sire to many of our future litters I decided to test him too. He is of course negative.
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Eventhough Ch Cozycreek Seven Diamond's grand-parents have been tested for the MyBPC mutation and are DNA negative, I decided to go ahead and have her tested too, she is of course negative.
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Eventhough Cozycreek White Mountain Heather's parents have been tested for the MyBPC mutation and are
DNA negative, I decided to go ahead and have her tested too. She is negative.
Eventhough Cozycreek I Love Sugar On Snow's parents are DNA negative for the MyBPC
mutation, I decided to go ahead and have her tested too. She is negative.
Eventhough both of Ch Cozycreek Blueberry Blossom's parents have been tested for the MyBPC mutation
and are DNA negative, I decided to go ahead and have her tested too, she is negative.
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Ch CathedralNH Sky Rocket of Cozycreek's parents:
HCM DNA RESULTS FOR:
CH CFF BRIER ROSE GI JOEY OF COZYCREEK
 Veterinary Cardiac Genetic Laboratory
EVALUATION FOR THE RAGDOLL FELINE HYPERTROPHIC CARDIOMYOPATHY
CARDIAC MYOSIN BINDING PROTEIN C MUTATION
TEST TYPE: THE MUTATION PREDOMINANTLY FOUND IN RAGDOLLS
Hypertrophic cardiomyopathy is the most common form of heart disease in the cat. In many breeds it is an inherited disease. Our laboratory has identified a mutation responsible for the gene in some cats. However, it should be noted that in human beings with the same disease, there are many different genetic mutations which can cause this disease. It is likely the same in the cat.
Very importantly, the absence of the mutation in this cat DOES NOT mean that it will never develop the disease. It means that it does not have this known mutation that can cause the disease in the cat at this time. In the future, additional mutations may be identified that may be tested for as well.
Cats that are positive for the test will not necessarily develop significant heart disease and die from the disease. Some cats will develop a very mild form of the disease and will live quite comfortably. We recommend annual evaluation by an echocardiogram and discussion with a veterinarian for treatment options if hypertrophy develops.
Importantly, breeding decisions should be made carefully. Removal of all of positive cats from the breeding population could be bad for the Ragdoll breed. Remember that cats that carry this mutation also carry other important good genes that we do not want to lose from the breed. We recommend not breeding the positive homozygous cats and, if needed, breeding positive heterozygotes to unaffected cats to decrease the risk of producing affected cats. As we move forward, we should try to select more and more negative kittens from these lines to use for breeding. Keep in mind that we are continually learning about this disease and recommendations will be altered as we obtain more information.
Date: 7/22/2007 Submitter Name: Suzette Garey
Cat ID: R481 Cat Breed: Ragdoll
Cat Name: Joey
Microchip Number (optional):
Test result for the DNA submitted for the above cat is: Normal / Normal
Result Based on the following sample(s) submitted for this cat: 2 Cytology Swab(s)
One sample does not provide a cross-checked result. Two samples provide a cross-checked result. A cross-checked result is recommended.
Definition of Possible Results:
Normal / Normal : Negative for the HCM mutation
Mutant / Normal : Positive Heterozygote for the HCM mutation. Heterozygotes have 1 copy of the mutated gene and 1 copy of a normal gene
Mutant / Mutant: Positive Homozygote for the HCM mutation. Homozygotes have 2 copies of the mutated gene and may have a greater likelihood of showing severe signs
Kathryn M. Meurs, DVM, PhD, Professor
Richard L. Ott Chair of Small Animal Medicine and Research
Washington State University- College of Veterinary Medicine
PO Box 605 , Pullman , WA 99163-0605 • 509-335-6038 • FAX: 509-335-3745 • vcgl@vetmed.wsu.edu
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HCM DNA RESULTS FOR:
CH CFA WHIMBREL TABITHA OF COZYCREEK
Veterinary Cardiac Genetic Laboratory
EVALUATION FOR THE RAGDOLL FELINE HYPERTROPHIC CARDIOMYOPATHY
CARDIAC MYOSIN BINDING PROTEIN C MUTATION
TEST TYPE: THE MUTATION PREDOMINANTLY FOUND IN RAGDOLLS
Hypertrophic cardiomyopathy is the most common form of heart disease in the cat. In many breeds it is an inherited disease. Our laboratory has identified a mutation responsible for the gene in some cats. However, it should be noted that in human beings with the same disease, there are many different genetic mutations which can cause this disease. It is likely the same in the cat.
Very importantly, the absence of the mutation in this cat DOES NOT mean that it will never develop the disease. It means that it does not have this known mutation that can cause the disease in the cat at this time. In the future, additional mutations may be identified that may be tested for as well.
Cats that are positive for the test will not necessarily develop significant heart disease and die from the disease. Some cats will develop a very mild form of the disease and will live quite comfortably. We recommend annual evaluation by an echocardiogram and discussion with a veterinarian for treatment options if hypertrophy develops.
Importantly, breeding decisions should be made carefully. Removal of all of positive cats from the breeding population could be bad for the Ragdoll breed. Remember that cats that carry this mutation also carry other important good genes that we do not want to lose from the breed. We recommend not breeding the positive homozygous cats and, if needed, breeding positive heterozygotes to unaffected cats to decrease the risk of producing affected cats. As we move forward, we should try to select more and more negative kittens from these lines to use for breeding. Keep in mind that we are continually learning about this disease and recommendations will be altered as we obtain more information.
Date: 6/22/2007 Submitter Name: Suzette Garey
Cat ID: R483 Cat Breed: Ragdoll
Cat Name: Tabitha
Microchip Number (optional):
Test result for the DNA submitted for the above cat is: Normal / Normal
Result Based on the following sample(s) submitted for this cat: 2 Cytology Swab(s)
One sample does not provide a cross-checked result. Two samples provide a cross-checked result. A cross-checked result is recommended.
Definition of Possible Results:
Normal / Normal : Negative for the HCM mutation
Mutant / Normal : Positive Heterozygote for the HCM mutation. Heterozygotes have 1 copy of the mutated gene and 1 copy of a normal gene
Mutant / Mutant: Positive Homozygote for the HCM mutation. Homozygotes have 2 copies of the mutated gene and may have a greater likelihood of showing severe signs
Kathryn M. Meurs, DVM, PhD, Professor
Richard L. Ott Chair of Small Animal Medicine and Research
Washington State University- College of Veterinary Medicine
PO Box 605, Pullman , WA 99163-0605 • 509-335-6038 • FAX: 509-335-3745 • vcgl@vetmed.wsu.edu
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Just for the heck of it I decided to have the PKD testing done on my white girl. This test has only been validated for Persians, Exotics, Himalayans, British Shorthairs and persian first generation outcrosses. PKD is not considered a problem for Ragdolls.
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